Dr. Martin Schiller at the 2016 Nevada Institute of Personalized Medicin...

Transcript

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what's gone on a difficult last year I

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me and then we're going to move on to

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the keynote cooking fair session so for

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the last chair you know like I have a

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vision of what it would be but by

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breathing on the six other on poor

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faculty and then how many 20 affiliate

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faculties we've worked together over the

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past year and kind of a real easier in

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one of the major problems that we would

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like an influence in Nevada so I think

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there's no growing consensus on this top

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number but approximately one in ten

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people suffer from a genetic disorder

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their other day on this and if you go on

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to the UK thousand genomes part of

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website they actually ate by age 65 one

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and two people may have a genetic

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disorder so this is something that's

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definitely going to be in the future of

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modern medicine um I put together this

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plot of the United States year and I've

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other two things against each other so

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there are 22 states designated by the

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NIH 15 idea states and these states

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don't have very much funding from an IH

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to do biomedical research if you notice

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Nevada is one of those states entendi

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Barton park with clinical genetics

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website and got the chances first aid

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the hatch for us if you notice is a

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pretty big importance on between this do

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and I think what this amounts to in the

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country is there's a growing health

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disparity that's about to get a whole

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lot worse because what it means is in

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these states where there's not a lot of

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biomedical research there's very little

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genetics that is making its way into

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clinic and that's the case in this state

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but you know I think Holly Morris of

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sitting at this table is the only one in

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Southern Nevada besides Michael who just

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passed his boards excellent so we don't

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have a lot going on in the state and

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this is something that knit one wants to

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help facilitate the group of Nevada so

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this will have other impacts as I've

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been packing the general health and

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well-being of Devine's right now um

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basically we're exporting all these

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genetic services the other states and

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some of our external advisors are in the

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states where according to do incredible

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on

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churches were out of that right and so

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the other thing nipple would like to do

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is to influence the clinical care and so

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in coming up with a strategy to know

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about this you know nipple needs to

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build a foundation and research and

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start clinical service thing we're

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expecting this will be eventually to

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education in clinical genetics and jobs

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that goes there drug you know later

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outcomes that on the collective right on

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the first ones so you know the promise

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of personalized medicine our keynotes

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people were going to this course while

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on dwell on it but today there are

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eighteen thousand diagnostic tasks there

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are twelve thousand main diseases

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including about 7,000 rare genetic

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disorders and our primary care systems

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is supposed to take a person and through

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a series of first first line test

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they're supposed to you know help you

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solve clinical problems but if it's a

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problem that is hard how do you navigate

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this space I think this is one of the

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potential areas downriver clear genetics

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will be able to play a really important

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role because if we know clinical

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outcomes from bearings and we can test a

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lot of bearings at once there's the

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potential to help guide patients through

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the health care system and so the

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general concept is right now we have

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this trial and error medicine and the

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genetics can be used to develop an

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informatics driven medicine really end

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up reducing costs and have better

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outcomes so from the genomic analysis

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basically this can help the diagnosis

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prevention and choosing optimal

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therapies now there's a number of your

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barriers to making this happen in full

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force and it should take a while for us

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to get there but doesn't mean that it

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can't be very influential it's better so

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one of the barriers in the country and

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this is why we want to have to one

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outcome be education is having trained

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staff with the existing numbers clinical

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geneticist in the country and genetic

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counselors there's no way to handle all

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of the potential patients that need this

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type of service knowing that the

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training programs in these areas don't

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produce the hydrocodone so there's a

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problem problem there so the staff is a

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barrier on one another barrier is

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is kind of get ingrained and having

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everyone all of a sudden start using

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genetics and their practice really isn't

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practical so it's going to take time for

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for physicians to get used to using this

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on a regular basis another issue is

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something who gets the leader in the

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afternoon variant interpretation and the

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genetics of common disease so today will

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you sequence someone most of what you

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find it hasn't been found before and

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maybe in a gene that is an important

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change we don't know if it really has

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infected on so this is a problem that

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has to be solved you're not going to

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just mention a poster we have on our

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familia american eagle t equal is that

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we think may be able to help with this

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problem downriver another issue this

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regulatory or right now the brakes are

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on on the fda and you know this is an

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issue going forward some think it's good

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because we need to learn more before

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this gets escalated and finally as

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insurance universe because they're this

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yet we need a financial model that works

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for society so the lower part we got and

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i'm very quickly in a year in review so

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a year ago we have our

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mass which was the keynote speaker James

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loves tea we basically talked Institute

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approved by the Board of Regents and we

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deployed website that we keep up today

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we recruited an external advisory board

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that's near today we're looking forward

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to our hitter through eating with that

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or second or third we've recruited staff

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and faculty at once in pictures here or

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core staff or faculty and then we also

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have about 20 affiliate faculty from the

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University they're working with us and

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several groups and advisory boards we

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are working on kind of establishing

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partnerships as we move forward with the

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research and a clinical effort on one of

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the partnerships we join was for Policy

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and how people are feeling about having

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genetic testing and we're working with

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people seek which involves several of

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the major personal

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groups in the country we also are

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working with several at several groups

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community and externally in all kinds of

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different ways they just better put it

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back of people that soft we don't have a

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formal relationship with yet but we're

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getting closer we started a seven-hour

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series actually but since we're

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recruiting we have five upcoming seminar

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events that you're all up and come to

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we'd like to thank the governor's office

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again for funding us but also on some

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people who have groups that have donated

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critical infrastructure or any kind of

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gifts or even supported events to Devon

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listed here I will go into the state of

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the research projects you think you've

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seen all the talks today and posters but

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we've had some insights going on one of

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my impressions from the morning session

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was just loud and this is just great I

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got this going on a year and have such

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really beautiful signs and it's like and

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I just put together all the papers that

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this group is published in the last year

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and it was 22 papers although I

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understand from last night one of our

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order goodbye

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has their publishing in a group that's

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our size but much work for the big

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public camera typing but there are five

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people who pull those chambers under 17

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I to that yeah that's pretty good

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Footwear spider to get

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Jerome you said we put out a lot of

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brands in the year on we applied for

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about 19 million dollars in funding

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we've already gotten about 1.5 million

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and we also not include any of the

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affiliate faculty grants of this for a

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few of us in info actually are

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partnering with another advisory board

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member jen kinds of the audience and i

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just repaired cobra grant and so some of

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us participate that friend we didn't

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count that either but it is fired us

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nipple is actually put out a program

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grant just a few weeks ago and i'm

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hoping to replicate where Justin able to

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do at the ruko center and in front of

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the clinical front on we hired a

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clinical geneticist likely staff who

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being morning session and he's been

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working diligently on getting a clinic

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up and running and it's also starting

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research projects so I look back at that

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and I'm pretty pleased with the first

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year and if we can grow a super amount

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next year

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so looking forward for 2016 we're kind

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of viewing this bog is where our

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pipeline is where we're going to take

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patients take biological samples see

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what's them catalyze them on a computer

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and then make the patient happy so where

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are we on these things so in the first

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on the bottom here you were pretty close

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to having our clinic up and running and

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will be located in the beginning with

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the practice on ult campus ok and we're

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also as part of the clinical genetic

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service but i guess i'm hoping clinical

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but we are going to be doing some trials

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in exercise the company name athletic

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gym and we're exploring other

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relationships at the moment that are

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getting closer as far as the we bought a

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sequencer it's here we're setting it up

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right now we hire faculty and we have a

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current search for someone to run the

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machine so we're building a genomics for

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them not beaches

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you know me but for others gain Nevada

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we reported with the supercomputing

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Center and switch we hired faculty that

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are all involved in genomics analysis

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and building and the point of database

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and we basically have these exercise

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than other trials going on so that's

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that's what we're hoping to get going

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next year we have some milestone

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centegra so moving on I'd like to

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introduce someone who's already done all

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this and gotten it going and he's our

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keynote speaker today dr. Kim Stewart

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from the Mayo Clinic and he is the

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director of the Mayo Clinic center of

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personalized medicine he does

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translational and basic and clinical

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research on multiple myeloma and he's

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identifying targets for therapy he was

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one of America's top doctors in 2014 and

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all of these additional Awards grants

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and research papers that have welcomed

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into and more details so I lived and get

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up here it's because that's what review